De hoofdrollen voor de verfilming van Fantastic Four zijn bijna allemaal bekend. In volkomen willekeurige volgorde:
- Ben Grimm/The Thing: Michael Chiklis
- Reed Richards/Mr. Fantastic: Ioan Gruffudd
- Johnny Storm/the Human Torch: Chris Evans
Fantastic Four is gepland voor 1 juli 2005 en wordt geregisseerd door Tim Story (Barbershop).
Hutch Parker van 20th Century Fox:
[eng]"We see 'Fantastic Four' as the last great jewel in the comicbook crown. The casting has been extremely important in terms of fulfilling expectations of an audience that's been incredibly loyal to these characters for over 40 years."[/eng]